Hi,
with NBU 7, you have two option, VCB or vStorage API. The first needs a VCB proxy host, the second needs an offhost backup host, both can be w2003 or w2008. You can backup all of your VMs without any agents, but with restrictions of course (for example no RDM). For vStorage API you have to upgrade vSphere to 4.1 IIRC. Any details of your VMs?
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yyaazz
http://tt.yyaazz.hu