Technically YES - as in vRO could update both AD datasets if the following conditions apply
- Both AD/DC hosts can be seen over the network from the vRO appliance
- Both are added to the inventory as different ADHost instances
In that case if you then had both ADHost instances as different attributes on the workflow it should be possible.
AFAIK though a windows server cannot be joined to two domains so this probably has no practical application...?
Happy to be corrected by a Windows admin though