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In a typical VMmark3 environment two clusters are set up for testing: the Client Cluster and the SUT (Servers Under Test) Cluster. The Client Cluster will contain the PrimeClient and the Client VMs used during the testing. The SUT Cluster will contain all the other workload VMs created and the template that is used for both creating all the VMs being tested and used as an Infrastructure operation (deploy a VM) during testing.
A cluster is made up of any number of ESXi hosts and the SUT Cluster is always a minimum of two hosts. You do not need 1 ESXi host per tile. If you look at some of the submitted results to the VMmark3 Results website (VMmark 3.x Results) you can get an idea of how many tiles can run on each ESXi host based on the type of processor (model, cores, frequency, etc) you are testing in your SUT Cluster.