Moderator: Thread moved to the vSphere vNetwork area.
If the all hosts in the clusters have common configuration you can use single VDS across all Clusters. If have different configurations like segregated network like DMZ network, Management network and Data network using seperate vswitch or dvswitch then I suggest to segregate the dvswitch accordingly. about uplink (vmnic) absolutely need to remove one uplink from each vswitch/dvswitch and attach to new VDS so keep running hosts and VMs. For best practice configration dvswitch you can look this guide. https://www.vmware.com/content/dam/digitalmarketing/vmware/en/pdf/techpaper/vsphere-distributed-switch-best-practices-wh…NS
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