Do I need to re-configure my Physical NICs or I am missing some steps ?
This is Nested Lab
Looks like a potential connectivity issue between VC,ESXI and NSX Manager. You have two interfaces for VC and ESXI and i suspect a routing issue in your set-up. Why don't you make NSX manager,VC and ESXI host in same subnet ? If that is not feasible , do a proper connectivity test between these components
1. Can VC reach ESXI and NSX ? Which interface/gateway is used for this path ?
2. NSX to ESXI/VC how is the communication path ?
3. If any firewall rules in place , ensure all required ports are opened.
4. Considering this is nested, potential MAC learning issues can happen . So Promiscuous mode will be required.