Is the physical computer they are locking at work different than the physical computer they are logging into when they get home? If so, then it sounds like the Protocol was changed from 1 machine to the next (e.g. VMware Blast configured at work, PCoIP configured at home.)
No...It's the same computer. Also....The protocol in use here is RDP since it's a physical Desktop. Has nothing to do with Blast or PCoiP.