It is possible in vRealize Operations Manager to mix Operating System Instance (OSI) and CPU based licenses.
If you mix different kind of licenses you need to create separate license groups for each type of license keys (one for CPU and one for OSI (VM)). It is recommended that you use non overlapping exclusive Licensing Groups to have the best advantage when you mix OSI (VM) and CPU licensing.
For more information have a look at VMware Knowledge Base
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