Hope you are doing good!
Please try to open the configuration page of the Skyline Collector in "incognito mode" and check if the configuration is getting saved.
If you are facing the same issue then please share the Skyline collector version.
Checking with customer if running in "incognito mode" saves the configuration. I'll reply when I get answer from customer. Thank you.
Customer was able to save Auto-Upgrade configuration using "incognito mode" and using supported browser. Thank you. This discussion can be closed.