vSAN doesn't care at all what licensing level ESXi has so changing this should have zero impact.
While DRS can be configured in just a few clicks, you are going to want to spend more time looking into the specifics e.g. partially/fully-automated, thresholds, resource pools and advanced options (e.g. which memory metric to use active or consumed) - which options you choose when configuring this is not something someone outside of your business can decide as it depends on what you want to achieve. So I would advise you read up on the basics of HA and DRS if you are unfamiliar with them so that you can then make an informed choice about how to configure it to suit this specific environment.