Hello Hesyam,
1. Yes, there are licensing implications regarding this, great info covering this in detail in this (current) document:
vmware.com/content/dam/digitalmarketing/vmware/en/pdf/whitepaper/solutions/oracle/understanding_oracle_certification_support_licensing_vmware_environments-white-paper.pdf
2. The above document details this, e.g. host-affinity rules, dedicated clusters for these applications, cloud-based alternatives etc.
Bob