Have you tried it?
The connection is simply an ODBC connection. It may not be supported, but it might work.
I tried installing VirtualCenter with a DB2 ODBC datasource today.
It failed, complaining about an incompatible datasource type (the datasource type was DB2/AIX64).
So, I guess the ODBC connection is not as simple as it might look like...
Any chance you got VC working with DB2?
I'd be interested also if anyone got DB2 working with VC.