The S2600GZ is on the vSphere HCL: Link You should be good there. As for vSAN, there are only three pieces of hardware on that HCL. I/O Controller, HDDs, and SSDs. Team the S2600GZ with items from vSAN HCL and it should be a supported config. Note, supported does not mean appropriate for all workloads. If it's a heavy workload make sure to get higher end I/O controller, HDD, and SSD. For the I/O Controller check the queue depth and whether is supports pass through or not. In pass through you can hot swap a drive in the even of a failure. If RAID 0 is required you need to down the host, replace the drive, and re-create the RAID 0. For the SSD, check the performance class AND the endurance class. The HDDs are pretty straightforward. The faster the better. The larger the better. SAS over SATA. Etc... Hope this helps, Zach.