Additional info, I do have 2 ESXi 5 hosts running on a Dell blade server that has DRS enabled to balance the load for all the VM's.
This is my note based on vSphere Networking Guide 5.1 p12 and p16. I refer to it every now and then. Assuming you are using VST (Virtual Switch Tagging) config, you need to make sure,
1. VMs in 5 of the pools that you want to isolated are mapped to the correct port groups (corresponding to vlan 50 and 60)
2. Trunk the correct uplink port on vSS/vDS and physical switch. A easy way is set both to 4095 but for security reason I usually allow only the vlans in use.
3. Then from physical switch you would trunk between edge and core and allow specific vlans (e.g. vlan 50 or 60) on different port on edge switch that your office hook into.
Hope this helps