You are absoultey right these tasks can be performed with any distrubtion to the ESX hosts/virtual guests what gets people caught out are the following.
Bad Zoning or Incorrect zoning across front end ports.
Incorrect pathing policy set on ESX hosts you can verify this with your storage vendor what it should be set to.
If you have these things right your good to go.
TheESP is absolutely right, assuming your mesh is accurately configured it should be no issue.
Check all those paths and zoning ahead of time before "yanking the plug"!