We are running ESX 3.5 hosts, so far all our VM's are 32bit Linux and Windows OS's. However, I am getting more and more requests to run 64bit OS's. If I do this, its possible both will get mixed together. Does anyone have experience running both on the same host.
One VM is just like the next. ESX doesn't care 32-bit 64-bit it's all the same. It's just a Virtual machine occupying CPU / Memory, that's it. There are no consequences to running 32-bit along side 64-bit.
They really aren't mixed, each VM runs in it's own memory / private space.
both 32 and 64bit VM's can exist together without any issues. You just need to ensure your Host ESX Server's CPU can support it.