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Different numbers of uplinks on one distributed switch

We have one cluster where all ESXi servers have 4 physical uplinks (LACP) and another cluster where all ESXi servers have 2 physical uplinks (LACP). Both clusters are connected to the same Distributed Switch.

The 4 uplinks handle alle traffic also vSAN. The 2 uplinks handle all traffic but not vSAN.

Can that design bee a problem?

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