every single time it needs to expand a SCSI reservation will be required. Now with the advanced locking mechanism vsphere has the locking mechanism has been relaxed so it shouldn\t be too big of an issue. on top of that you could also, if your array is capable, leverage VAAI capabilities to offload the locking and do it on a block level vs datastore level.
Again, I spoke extensive with Satyam about it and you shouldn't be too worried. Especially if you are not overloading the array/datastore.
Duncan (VCDX)
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