We are using Acronis vmProtect 8. This backed up fine for many months.
We started using vSphere Replication with the 'MS Shadow Copy' quiescing enable. After two days the vmProtect backups started to fail. We noticed a lot of change block tracking .ctk files per virtual disk and snapshot delta vmdk.
In the end we had to delete the .ctk files and consolidate as per kb article 2013520.
Can vSphere Replication using quiescing ever work with backup software?