@nblr06,
Heterogeneous datacenters are not an issue as the replication is mainly copying data from one side to another, the issues could appear in terms of performance at the time of a failover as the VMs are currently running on vSAN and the performance from the VMFS could be different but you will need to do some tests to see how your applications work.
Now, for the maximum number of replications, it will depend on the Configurations Maximums of vSphere Replication which is not related to vSAN/VMFS (unless you are using vSAN ESA added in vSphere 8).
Regarding your last question, yes, vSphere Replication replicates the data with a minimum RPO o 5 minutes, however this is not synchronic as Fault Tolerance but asynchronic as it cannot be seconds.