Depends on what you are trying to accomplish.
1. Do I need to install VR appliance for Both Sites: Source & Target or just the target site. -- For a single vCenter Server managing both sites, then no need to deploy a 2nd VR appliance. If both sites have vCenter Server, then yes you need to have VR appliance at both sites.
2. Do I need to have a VCenter on both sites? This is the preferred method for DR purposes but not a hard requirement to get VR working.
Or can I use a the VCenter at my soure site to manage the ESXi host at the target site ? Yes you can. You can even protect your vCenter Server if its a VM by replicating it to the target site.
3. Can a Vcenter manage ESXi host located at different subnets / network ? Yes as long as routing is there and firewall ports are open.
Regards.
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