It has been a few years (and a few version iterations) since this question has been asked, and I'm hoping the answer will be different at this point.
I am looking for a way to automate initial configuration of vSphere Replication. I doesn't matter if it is API based, ESXCli or PowerCLI Cmdlets.
There is information about, it seems that with the .ovf tools someone used a script to configure the deployed tool.
More information: https://www.virtuallypeculiar.com/2017/06/automating-vsphere-replication.html
Script used: GitHub - happycow92/vsphere-replication-deploy: Script to deploy vSphere Replication appliance from ...
Yes you can automate vSphere Replication using vRealize orchestrator.
Refer to the below blog post, which explains and has a demo to how to automate?
Using vRealize Orchestrator 7.3 to Automate vSphere Replication 6.5 | Victor Virtualization
I'm sorry my original ask was not specific enough. We have the Replication appliance online and configured. Where we struggle is when a client comes to us and says they want their servers replicated and they provide a list of 20-30 servers. It would be much easier if we could automate the initial replication setup of the VM in the environment.