I am curious if anyone has experienced sluggish performance after their upgrade to 4.2.1 from 4.2.0. I am using the vCO appliance. I upgraded to 4.2.1 and also installed any plugins that had newer versions (just to make troubleshooting all that more fun!). I have removed all old workflow runs and cleared out the temp files which "feels" like performace is a bit better but still pretty sluggish. I have taken a cursory look at my environment and I don't see anything which looks to be out of the norm.
Yes, unfortunatelly most likely this point to a know issue. A new update release of the vCenter plugin would be provide around mid of June. You can open a Support Request if you want to get the updated version earlier. Sorry for the inconvience.