Can multiple VIX clients work with one vCenter?

I am working with an application that uses VIX API to access a single  ESXi box. I'd like to expand to several ESXi boxes, managed by vCenter. Can multiple client applications use VIX to manage VMs across several ESXi boxes, via a single vCenter instance? Based on other discussions I would say I could, but I didn't see anything that addressed this issue directly.

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