if the installer is asking for an uninstall of the previous version, then proceed. All your information is stored in your DB, so just ensure you have a good backup.
Also, I would turn DRS to 5 stars if you have it fully automated. During the vpx agent upgrade process sometimes DRS will start shuffling things around. Once all agents have been upgraded, i usually enable DRS again.
Great point with DRS. I'll give it a try.
I was hoping that there was just an Update 2 patch I could download and apply. I guess not though.