You can have 2 cluster in vcenter4, but not mixed. would be a cluster and another ESX3.5 vSphere until all hosts are on the same version.
You can run the machine with virtual hardware version 4 in Host vSphere but not virtual hardware version 7 in ESX 3.5
to add hosts esx3.5 in vcenter4 , disconnect host, remove and add in vcenter4
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