Thanks for the responses - I should have been a little more specific since this is a pretty ambiguous question. Thanks to you both for the information thus far.
I plan on running Hyperic on a pretty nice server, dual quad cores, 4gb of RAM, and a couple 15k SAS drives.
The server will be monitoring about 10 servers total, possibly up to 20. I want to be sure that I install it right the first time to avoid headache down the line.
Assuming I don't run out of hard drive space any time soon, do you think it's reasonable to expect that the built-in postgres DB will work for me?