As you have noticed, Persona Management isn't a very popular choice for profile management as there is little to no information available about troubleshooting such issues. This has many reasons. If you want to get proper information about your case, I would suggest to contact VMware Support for this (GSS).

Something you should also consider is the fact that VMware Horizon 6 does not support any Windows 10 release after 1709.

Check this article for more information:

Supported versions of Windows 10 on Horizon Agent Including All VDI Clones (Full Clones, Instant Clones, and Linked Clones on Horizon 7) (2149393)

VMware Knowledge Base

Windows 10 releases also have their lifecycle, depending on the version (pro, edu, enterprise). See this article for more information and specific EOL dates for all Windows 10 releases: https://support.microsoft.com/en-us/help/13853/windows-lifecycle-fact-sheet