It's an annoyance. There is always some piece of software that you absolutely need, if only for 10 mins, and it inevitably runs on whatever OS you don't have installed on your main workstation. 

VMWare is easily reliable enough to run an enterprise on. It *is* rather Intel specific though, so if you need to do something for an IBM Mainframe, AS/400, HP9K, or whatever, you are usually out of luck. Or in some cases, running an emulator. 

I really like VMWare. Once processor speeds catch up enough to do really good hardware emulation, I think VMWare will be what everyone uses. Docker and Redshift not withstanding!