@jamesdoe For what it's worth I ran a little experiment with my Windows 11 ARM VM.

I do some tinkering around with programming Arduino single board microcontrollers. The IDE for this board communicates with the board over a USB interface. The USB interface is used to both download software to the board and view a serial output device (over the USB port) provided by the board. I've used the IDE on Macs and Windows x64 (yes, even VMs).

I installed the IDE software designed for Intel Windows onto my Windows 11 ARM VM. From initial testing, it seems to recognize and communicate successfully with the board when USB connected to the VM. Software downloads to the board and view of output over the board's USB serial device both work as they did on Intel Windows.

My gut says you have a better than even chance of your software working with the USB. Of course, you probably won't know for sure unless you try it out.