Hi vmstrom,
Are you sure this happens specifically with the "Remove Local Profile at Logoff" setting? Or is this happening in general? What happens when you disable/remove the "Remove Local Profile at Logoff" setting and let a user log off and log on to a different VDI desktop in the pool? Are Edge and Calc available then?
I am trying to understand if this is a configuration issue/bug or if this is happening because of a Config File issue (or the lack of the existence of one).
B.t.w. you may also consider to recreate the VDI desktop at logoff, if possible.