@JonathanMcEvoy . That's a very good question.
First, what are really the requirements for that. TPM is only one thing. Installing from ISO is yet another thing and what does it mean that not all Upgrades are possible. Just today, it was said "Automatic Updates" are not possible if you install from ISO - who cares? Companies don't use it anyway, or is a company update-policy considered as Automatic as well, since that is limited Automation for updating? If there is no TPM on the HOST, does it matter if VMware has a virtual TPM? Does the Host processor matter if VM has TPM?
There is a myriad of questions around and Microsoft stories just change weekly and nowadays appear to change daily.