Thanks for your suggestions. We do not have the license for UEM and have been using Persona successfully with Horizon 6 and Win 7, so we hope it will work the same with Horizon 7 and Win 10. I am having a hard time finding documentation for Persona with Horizon 7. We are using Win 10 1803.
I am wondering if not using the mandatory profile could be the issue.
I did not setup our Horizon 6 Persona environment so it is a little learning curve for me, but I imagine I could use mandatory profiles with it. But I am tending to agree with you that I may just leave Sysprep out of the equation and follow the guidelines similar to VMware Horizon 7.5.1 – Master Virtual Desktop – Carl Stalhood which I have done successfully before. Unfortunately I am running up against a deadline and do not have a lot of time left for experimentation.