Z80 
I wrote an assembler and virtual machine engine -including simulating IO- for running the code straight on an IBM clone a long long time ago.
At the time I never heard about "virtual machines" but we had some Z80 kits at school and this way one could run the code without access to the kits.
The teacher wasn't impressed.
The vDOS project has wandered quite a bit of the track on DOSbox, I'd wager to say the core part has been rewritten. I looked at what the author has done. It's pretty cool.
No checkbox for what you are looking for in VMware and yes I remember the time before the mouse.
Walking on memory lane, here's a screenshot: Twitter: Awesome, bumped into sth I wrote in 1988…
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Wil
