You are welcome. I'm glad it helped you out 
Yes, you can change it by changing isolation mode in directory %Appdata% in file ##Attributes.ini. Then delete all ##Attributes.ini files in all directories under %Appdata%. This makes isolation mode to be inherited from parent directory %Appdata% to all its children directories.
There is no side effect. All disk changes under directory %Appdata% will be handled as isolation mode declares as I wrote in my previous post.
Have a nice day,