Yes, you can, provided they are in different folders.
Same goes for VMs.
You can select a specific VM by adding for example the folder.
Get-Folder -Name MyFolder | Get-VM -Name MyVM
If you are using Get-View, you can use the Folder as the value for the SearchRoot parameter.
$folder = Get-Folder -Name 'MyFolder'
Get-View -ViewType VirtualMachine -SearchRoot $folder.Id -Filter @{Name='MyVM'}
Another option is to use something like my Get-VIObjectByPath function.
Just be aware that it returns a vSphere object (the same as what Get-View returns).
To convert that to a .NET object you will need to use the
$obj = Get-VIObjectByPath -Path 'MyDatacenter/MyFolder/MyVM'
$vmView = $obj.Node
$vm = Get-VIObjectByVIView -VIView $obj.Node
