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VirtualSpence
VMware Employee
VMware Employee

According to the interop matrix, App Volumes 4.0.1 is compatible back to Horizon 7.10.0: VMware Product Interoperability Matrices

You can use the 2.18 agent with a 4 manager, but there are some considerations. Check out the App Volumes 4 Installation and Upgrade Considerations guide and check out the section on coexistence.

Josh Spencer Staff Architect – Technical Marketing End User Computing, VMware, Inc.