Chris, welcome to the forums.
Thats a good size deployment. Do you have en experienced VMware architect involved to assist? A few days in their head is going to get you a long way fast. Thats my first recommendation.
Second, why do you want reservations. A CPU reservation on the VM gives the resource to the VM if it needs it or not (opposed to pool reservations). So you are going to waste a LOT of CPU that could be used by machines that do want it. (Someone will correct me if I am wrong here, its to avoid any ramp up latency). Sure you may have some specific VMs that need a reservation but that should be an exception and a very rare one and not a rule. You want to be thinking about shares and resource pools more.
Have you done your sizing analysis yet? Worked out your VM per core rations, RAM per VM ratios (in normal model and in maintenance mode, aka down a host). Have you done your cluster sizing yet? Are you scaling up or scaling out. If you don't get the balance of RAM vs CPU right you are going to waste a bit of money. Has VMware or a partner run a Consolidation Estimate yet? It has good data to feed this analysis.
Keep us posted of your progress and good luck.
Rodos
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Rodos
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