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Jeroenix
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I would also restrict VMs memory/processor/IOPs usage of the development machines by using resource pools. What you also might want to look at are "VM rules". You could configure things so, that certain groups of VMs would run only on certain designated hosts, thereby forcing all the dev/test machines together on a certain host, reducing the risk to production.

To make your production machines more robust, you could use those same VM rules to spread certain cluster-aware application servers across the ESXi-cluster, so for example your SQL mirrors or Domain Controllers won't be on one physical machine. This can of course only be applied if you have such servers.

VM rules are found under DRS in the cluster properties.

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