The Web Client was a major factor in our I.T. Dept trying out Nutanix AHV. It is on par with VMware in performance, and light years ahead of VMware in ease of management. I have yet to come across any issues with compatibility.
We have been slowly migrating work loads off of VMware into AHV for the last couple of months with absolutely no ill effects. With every passing day, I have to go into vSphere less and less often. I could not be happier.