Older thread but still relevant. I have essentially the same hardware and I'm literally in USB hell. Passthrough of onboard USB devices causes the VM (Windows 10 with an NVidia GPU) to simply not boot if a device is attached to the controller. Even the USBc on the RTX 20XX video cards. For example I can boot up a VM, attach a USBc hub to the video card and the mouse and keyboard will work fine. Reboot and the VM will hang (but not crash the host). Remove the USBc hub and its fine. HID passthrough is flakey at best and I have no idea how to manage multiple exceptions for the /bootbank/boot.cfg file. I literally cannot get the VM to boot if any USB device is attached to a passed through controller. I haven't tried the D3D0 option for the Starship controllers yet. PCIE card with ASmedia 1142 chipset won't work either...actually it doesn't work at my office on ESXI approved servers either so no surprise. I may end up buying some ethernet to USB hub servers. Not ideal so I'm hoping for any guidance! Thanks