Hi
When it comes to NUMA configuration you should consider a lot of things. I am going to go to your configuration directly. when you create a VM with less vCPU and more cores per socket, you had actually created some small domains of resources (you can check this with "Coreinfo" tools from Microsoft Sysinternals or check your vmware.log file and look for VPD to PPD), so as guest os view you have more than 2 NUMA nodes but in your physical environment, you only have 2 NUMA nodes, so some of your data will be reachable from remote memory DIMMs.(depends on your application behavior)
The only reason that you need to create this kind of VM with this configuration is "licensing" or maybe some specific situations, so from the NUMA perspective, I suggest keeping your cores per socket as low as you can (1 is the best) and increase your vCPUs unless you have another reason. If you have some kind of reason for this configuration, you can use "numa.consolidate=false" for your VM.
I hope this could help you
