Hello @depping
Thanks for you replay, I really respect you, and your very useful articles on yellow brick.
As you mentioned, with 3 host is impossible to make wrong decision, 3 host are equal 3 FTD, If I'm not mistaken, when the cluster is configured as stretched cluster number of FTD will be again 3, and should be same as 3 host, and wrong decision would be almost impossible.
In meantime I found another your article for the same topic, https://www.yellow-bricks.com/2020/12/14/vms-which-are-not-stretched-in-a-stretched-cluster-which-po... , according to this article, referring to second part, for using none-standard policy, if I understand correctly, main concern here is that those VMs will be without local resiliency, but they will have site resiliency.
Potential issue would be in case of failure of Site A VM on site A will read data from objects stored on Site B, which can have impact on the performance due to that the traffic will go over ISL link. If this is acceptable for those VMs, or if two site are close and directly connected i.e. in same campus then even this shouldn't be an issue.