I too am seeing a very similar problem with the VMware Workstation Player 16.2.x branch.  I have been able to repeat this problem on Ubuntu 20.04 through 21.10 hosts and on two different machines, a Xeon desktop and a Alienware laptop.  Both are running the latest NVIDIA binary drivers (510.47.03), but the problem existed with older drivers.  The previous Workstation Player 16.1 .x version does not exhibit the issue.

The mouse alignment problem shows up when running the LTSpice circuit simulation program from Analog Devices.  In this program you have to click on signals to display the simulation results on a scope.  The mouse pointer looks to be aligned over the proper signal marker but the system records the click at a point offset from the mouse pointer.  It is interesting that this problem occurs no matter if I'm running LTSpice natively in a WIndows 10 guest or running it under a Wine emulation layer inside a Linux (Ubuntu) guest.  I think the problem is related to LTSpice changing the cursor from a pointer to a custom bitmap.  I think there is something about the way the custom mouse pointer bitmap is being handled that is causing the offset problem.  The Sketchup Make 2017 modeling tool that is also experiencing the problem looks to be doing the same thing in that the mouse pointer is a pencil instead of a standard pointer.

I am hoping the clue with the application changing the mouse pointer helps identify the source of the problem.  I have been able to get used to just aiming off the place I need to click, but it is definitely an annoying bug.