Based on the logs, you have two very nice 4k monitors ;).
Due to Log4J, many companies including my own had to rush to Horizon 2111. First issues we encountered were graphical in nature, typically due to older Horizon 5.x clients.
I agree that this isn't a networking issue, the PCOIP logs indicate no high RTT latency or packet loss. The behavior though can indicate the VM itself is freezing in vSphere, either due to a large VM CPU spike or constrained vSphere Cluster resources.
However, I actually faced this exact issue a few months ago. New versions of Horizon and the Horizon client just don't offer any love for multiple 4k monitors. In the logs, you will see multiple entries for "unsupported display types/resolution." Instead, uninstall Horizon Client 2111 and drop in 2103.
Should be smooth going from there unless it is resource constraints in the datacenter.
