Running 6 hosts with NVIDIA GRID cards, ~200 people between two non-persistent linked clone pools, one running the M10-0B profile, for users with a single monitor, another running M10-1B for users with dual monitors. I also have an older cluster without GRID that I've seen this on as well.

I've heard from a lot of users that they are suddenly seeing a lag between when they type on their keyboard, and when their words appear on the screen. The lag ranges from annoying to unusable. It doesn't seem to matter if they are on a PCoIP zero client, or on a Blast thin client, or on a thick client with the Horizon app installed.

Really strangely, the lag is worse in Chrome and Outlook. I initially was looking to the GPUs, as both of those applications are accelerated by GPUs, but the other cluster without GRID has the same issue. 

All the articles I've read state that it's high CPU ready times, but when I look at the charts in vSphere, ready time is under 0.25 per core, which should be perfectly fine.