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Well you can only be certain by testing in development before making the change on production servers. I would also strongly consider a backup and recovery plan. I searched and couldn't find anything other an the PCOIP external IP that seemed to stick out. You should double check the host file for the paired connection broker and security server to make sure no one has made any modifications that would be tied to the old IP.
If things don't work out you should be able to quickly remove the security server, reinstall, and pair it with a connection broker by new IP rather quickly.