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Yes you always need AV. Imagine your users surfing the internet with no AV, infecting your machine and using that as a host to do nasty things to the rest of your network.
yes you can reboot to undo any harm to the local machine, but imagine a worm that infects your VDI every time after it reboots.
You can mitigate the effect of AV faull scans by scanning your master image and doing a recompose each week, if your security policy dictates a weekly full scan. For persistent images, there are other solutions/workarounds