To resolve the issue with the mouse wheel scrolling in VMware guests, ensure you have the latest version of VMware Fusion installed on your macOS host. Install VMware Tools within the virtual machine guests for better mouse integration. Adjust the mouse settings directly within the guest operating systems, specifically in the Mouse or Mouse and Touchpad settings in Windows XP and Windows 10 guests. If possible, test with a different mouse to rule out compatibility issues. Consider reinstalling VMware Fusion if the problem persists. Seeking assistance from the VMware Fusion support forums or contacting VMware support directly may provide further guidance.