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Hello,
I would look at esXpress, Veeam, or vRangerPro/vReplicator as a start. Even if you do not do differential backups, the backup time itself is going to be your key factor. You can only push so much data over the link. Backing up all 300GBs every night will take hours even with compression, etc.
I would take all three and get demo licenses so you can see the performance and data transfer requirements for each of the products. That is how I did my comparison. but each person's SAN and infrastructure is quite a bit different and times will change.
Best regards,
Edward L. Haletky
VMware Communities User Moderator
====
Author of the book 'VMWare ESX Server in the Enterprise: Planning and Securing Virtualization Servers', Copyright 2008 Pearson Education.
Blue Gears and SearchVMware Pro Blogs -- Top Virtualization Security Links -- Virtualization Security Round Table Podcast
Edward L. Haletky
vExpert XIV: 2009-2023,
VMTN Community Moderator
vSphere Upgrade Saga: https://www.astroarch.com/blogs
GitHub Repo: https://github.com/Texiwill