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If you absolutely need to guarantee 100% uptime I think you shouldn't be looking for a workaround which MSCS / HA / VM Monitoring / App Monitoring essentially is. All these solutions provide a mechanism to increase resiliency which wasn't added by the developer. The only way to guarantee no data loss would be a combination of of the mentioned workaround but even more important a well architected application. Distributed Databases combined with multiple App and/or Web servers would definitely add another 9. I suggest to first start looking into frameworks like Springsource.
Duncan
VMware Communities User Moderator | VCDX
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Soon to be release: vSphere 4.1 HA and DRS deepdive (end of November through Amazon.com)